CHangan生化课间绪论.pptVIP

生 物 化 学 第一章 绪论 厚德 博学 精诚 济世 厚德 博学 精诚 济世 生 物 化 学 第一章 绪论 优秀精品课件文档资料 Biochemistry Zhangguangxian Ph.D zhangguangxian@gzhtcm.edu.cn QQ:TelIntroduction What is the Biochemistry ? History and development? What is the Biochemistry discussion? Biochemistry and Chinese medicine? Biochemistry Definition: The chemistry of life The science concerned with the chemical basis of life The science concerned with the various molecules that occur in living cells and organisms and with their chemical reaction Anything more than a superficial comprehension of life – in all its diverse manifestation - demands a knowledge of biochemistry Biochemistry Aim: to describe and explain, in molecular terms, all chemical processes of living cells Structure-function Metabolism and Regulation How life began？ The scope is as wide as life itself Biochemistry Significance: be essential to all life sciences as the common knowledge Genetics; Cell biology; Molecular biology Physiology and Immunology Pharmacology and Pharmacy Toxicology; Pathology; Microbiology Zoology and Botany Biochemistry Medical students who acquire a sound knowledge of biochemistry will be in a strong position to deal with two central concerns of the health sciences: (1) the understanding and maintenance of health (2) the understanding and effective treatment of disease History and development? 1903 Neuberg 首先提出生物化学概念 发展：静态—动态—机能生物化学 1953 Watson and Crick DNA双螺旋结构 （分子生物学） 1972 Berg gene engineering 1976 Kan 胎前检验 beta-地贫 1977 Shine 克隆了人生长激素抑制基因 1982 Cech发现四膜虫rRNA可自我剪切 （Ribozyme） 1986 Mullis PCR技术 1990 基因治疗进入临床（ADA） 2001 HGP完成---后基因组学时代---蛋白质组学—生物信息学 1903 年 Carl Neuberg首次提出“生物化学” A pioneer biochemist, Carl Neuberg (1877-1956) spent over thirty years of his productive career as a professor at the University of Berlin (1903-1937) and as Director of the Kaiser Wilhelm Institutes of Biochemistry and Experimental Therapy. His varied research interests resulted in important con