卒中、类风湿关节炎和同型半胱氨酸关联因素.docVIP

卒中、类风湿关节炎和同型半胱氨酸关联 素 ［ ］自从人们认识到同型半胱氨酸水平升高 可独立引起动脉粥样硬化性血栓形成及血管内皮损伤并将 其命名为高同型半胱氨酸血症，它一直都是研究的热点。不 仅如此，同型半胱氨酸和类风湿关节炎的关系也尤为密切。 同型半胱氨酸可以引起血管损伤并改变一些特定蛋白质的 结构，造成新的可能会引起自身免疫反应的抗原的产生，因 而同型半胱氨酸有可能是引起一些自身免疫疾病如类风湿 关节炎的启动因素。这提示同型半胱氨酸和一些自身免疫疾 病的相关性。同型半胱氨酸可以通过免疫-炎症作用引起心 脑血管的损害。而免疫-炎症反应可能会增加同型半胱氨酸 的水平，并损害特定的组织（心血管疾病中的血管内皮损伤、 类风湿关节炎的滑膜损伤）。同型半胱氨酸和自身免疫疾病 （免疫炎症反应）之间存在这样的双向作用。在本综述中， 将阐述同型半胱氨酸作为卒中和类风湿关节炎之间的关联 因素的合理解释，认为同型半胱氨酸是引起卒中和类风湿关 节炎的因素之一，可以对这一点进行干预从而防控这两种不 同的疾病。 ［关键词］同型半胱氨酸；炎症；自身免疫疾病；卒中; 类风湿关节炎 ［ ］R743. 3 ［ ］A ［ ］ 1673-7210 (2013) 11 (c) -0032-07 The associated factor between rheumatoid arthritis， stroke and homocysteine LI Yushengl Avinash Chandral YU Hui2 WANG Hailil XU Yumingl 1. Department of Neurology, the First Affiliated Hospital of Zhengzhou University, He? nan Province, Zhengzhou 450052， China ； 2. Department of Tumor Radiology, the First Affiliated Hospital of Zhengzhou University, He’ nan Province, Zhengzhou 450052， China [Abstract] Ever since increase in homocyseteine (HCY) level termed as hyperhomocysteinemia (HHCY) has been recognized as one of causal factors for an independent factor for the atherothromobosis and endovascular injury, it has become an element of great interest of research. HCY has close association (between HCY and different diseases) particularly in rheumatoid arthritis ( RA ) and in cardio and cerebro-vascular diseases. The capability of HCY to the vascular damage and structurally modifying specific proteins, resulting in formation of neo-antigens may also be a. triggering factor of autoimmune reactions and thus HCY has probability to present itself as an initiating factor in autoimmune disease like RA. These all circumstances point towards potentially relevant role of HCY in the onset of specific autoimmune disease. HCY causes or plays a role in the progression of the associated cardiovascular and cerebrovascular damage through its inflammatory property. Immuno-inf 1 animatory activation may contribute to the increase in HCY level which in turn may