线性柱色谱分离过程的递推方程.PDF

2002 年第 60 卷 化 学 学 报 Vol. 60 , 2002 第 6 期 , 1088～1094 ACTA CHIMICA SINICA No. 6 , 1088 ～1094 线性柱色谱分离过程的递推方程 ① 梁　恒 　　董艳花 (西安交通大学分离科学研究所 　西安 710049) 摘要 　依据非平衡热力学分离理论中的局域平衡假设和流体力学的 Lagrangian 描述方法 ,首次提出了线性柱色谱分 离过程中溶质带迁移和扩散的状态递推方程 ,克服了以经典动力学为基础的塔板理论不能准确预测时变控制条件 下溶质扩散的局限性. 反相色谱梯度洗脱的实验数据支持递推方程的理论预测 ,与基于塔板理论的预测方法比较 , 状态递推方程法更具优越性. 状态递推方程还为采用动态优化控制柱分离过程奠定了基础. 关键词 　非平衡热力学分离理论 ,状态递推方程 ,溶质迁移和扩散 , 梯度洗脱 State Recursion Equations in Linear Column Chromatography Separation Processes LIANG, Heng 　　DOGN , YanHua ( Separarion Science Institute , Xi ′an Jiaotong University , Xi ′an 710049) Abstract 　Based on the local equilibrium assumption in nonequilibrium thermodynamic separation theory (NTST) and Lagrangian description in hydrodynamics , state recursion equations ( SRE) concerning zone migration and spreading were obtained. It overcomes the limits of plate theory which fails in accurate predicting zone spreading of the linear column chromatography separation systems with timevarying operation parameters. The experimental data of reversedphase gradientelution liquid chromatography support the theoretical predictions with SRE. It is more accurate to predict the zone spreading with SRE than predictions with plate theory in timevarying external force fields. The discovery of SRE lays a foundation of multistagecontrol and dynamic optimization of column separation with NTS