研究生英文文献汇报系列.pptxVIP

Infant Gut Microbiome Associated WithCognitive Development婴儿（2岁时）的认知发育与（特定种类的）肠道微生物有关;Contens;Words;Background;1.The gut microbiome is a complex microbial ecosystem that varies between individuals and may be a key modulator of neurodevelopment through the microbiome-gut-brain axis（肠脑轴）. 2.In rodents, experimental manipulations that alter the intestinal microbiota impact anxiety and depression-related behaviors . 3.In humans, altered microbial composition of the gut has been reported in children with autism and adults with depression and is linked to childhood temperament and adult cognition.;4.No studies have addressed when these relationships emerge or directly examined which brain regions may be involved. 5.A relationship may exist between concurrent(同时发生的) gut colonization and brain development processes. ;Objectives;1.In this prospective, longitudinal study, the researchers tested whether the 1-year-old gut microbiome was associated with cognitive outcomes at 1 and 2 years of age. 2.They hypothesized that infant gut microbiome samples would cluster into groups of community similarity and that cognitive ability would differ between clusters.根据群落相似性，肠道菌群样本可以聚类为不同的组，而聚类到不同组的婴儿可能具有不同的认知能力;Methods;1. Study Population;2. Microbiome Analysis（微生物群分析方法）;3. Genera Analysis and Co-occurrence Networks;4. Cognitive Testing;5. Structural Image Acquisition;6. Image Analysis;7.Association of Cognitive and Brain Outcomes With Cluster Membership and Alpha Diversity;7.Association of Cognitive and Brain Outcomes With Cluster Membership and Alpha Diversity;8.Metagenome Prediction From PhylogeneticInvestigation of Communities by Reconstructionof Unobserved States;Results;1.Infant Microbiota Cluster Into Three Groups Cluster 1 (C1) characterized by a relatively high abundance of Faecalibacterium;第一组的普氏菌属细菌丰度较高 Cluster 2 (C2) by a relatively high abundance of Bacteroides;第二组的拟杆菌属细菌丰度较高 Cluster 3 (C3) by a relatively high abundance of an unnamed genus in the family Ruminococc