复方甘草酸苷对SLE患者CD＋4CD＋25T细胞.DOCVIP

复方甘草酸苷对SLE患者CD＋4CD＋25T细胞的表达及狼疮损伤指数的影响 李毓阳1 戴永江2 邓斌2 粱雄安2谢志杰1 何升腾1 (1海南省农垦三亚医院皮肤科 海南 三亚 572000 2海南省医学院附属医院皮肤科 海南 海口 570102) 摘要 目的：研究复方甘草酸苷对系统性红斑狼疮(SLE)的治疗作用机制及其对SLE器官损害的远期疗效。方法：2008--2010年住院及门诊的SLE患者68例，随机分为以复方甘草酸苷的治疗组34例(简称治疗组)和单纯西药治疗的对照组34例(简称对照组)，正常健康组21例，用流式细胞仪检测SL E患者治疗前后和正常对照者的外周血CD＋4 CD＋25T细胞阳性率，及SLE损伤指数(SLICC／ACRDI )的研究。结果：CD＋4CD＋25T（%）两组治疗前与正常对照组比较，有显著性差异，P＜0.05 ，治疗后两组比较，有显著性差异，P＜0.05，均有明显降低；治疗后治疗组与与正常对照组比较，无显著性差异，P＞0.05，对照组与与正常对照组比较，有显著性差异，P＜0.05； 而SLE损伤指数积分显示，治疗组比较稳定，对照组较治疗前有明显增加。CD＋4CD＋25T细胞百分率与狼疮活动指数呈显著正相关。结论：提示以复方甘草酸苷对SLE患者的CD＋4 CD＋25T有明显的明显升高作用，并对SLE的器官损害有明显的保护与修复作用。 主题词 系统性红斑狼疮 ，复方甘草酸苷，T细胞，S L E损伤指数 系统性红斑狼疮（systemic lupus erythematosus,SLE）现在认为自身免疫耐受异常在SLE 的发病和发展中占主导地位近年来已有大量的动物研究证实，一种CD＋4C D＋25 T调节性T细胞（regulator T cells, Treg）在维持自身免疫耐受中发挥重要作用[1]。常规采用糖皮质激素治疗虽可控制SLE，但SLE的副作用及反复发作不容忽视，中药复方甘草酸苷具有重要的调节机体体液和细胞免疫功能的生物学效应，同时能有效预防激素的不良作用。本研究复方甘草酸苷治疗SLE前后C D＋4 C D＋2 5 T细胞的表达及狼疮损伤指数的影响。现报道如下。 Glycyrrhizin on the SLE patients with CD +4CD +25T cells and lupus damage index of Abstract Objective: To study the glycyrrhizin on systemic lupus erythematosus (SLE) and its therapeutic mechanism of long-term organ damage in SLE patients.Methods: 2008 and 2010 inpatient and outpatient 68 patients with SLE were randomly divided into the glycyrrhizin treatment group, 34 patients (the treatment group) and the control group treated with Western Medicine 34 (referred to as the control group), normal healthy 21 cases with flow cytometry SL E patients and normal controls before and after peripheral blood CD +4CD +25T cells positive rate, and SLE damage index (SLICC / ACRDI) study. Results: CD +4CD +25T (%) groups before treatment and normal control group, there was significant difference, P 0.05, after treatment between the two groups are significantly different, P 0.05, were significantly lower; the treatment group and with the normal control group, no significant difference, P 0.05, control group and the normal control group, there was significant difference, P 0.05;