家犬体内可降解输尿管支架管的降解过程及输尿管-第三军医大学学报.DOC

PAGE [通信作者] 李 虹，电话：（028E-mail：davidwung@163.com 消旋聚乳酸输尿管支架管在家犬体内的降解变化及输尿管病理学表现 王 炜1 李 牧1 刘绍虔1 徐 缓2 李 虹3 （523000 广东 东莞，广东省东莞市人民医院泌尿外科1；610041 成都，四川大学华西医院：病理科2，泌尿外科3） [摘要] 目的 观察消旋聚乳酸输尿管支架管在家犬输尿管内的降解变化以及输尿管组织病理学表现。方法 经手术将消旋聚乳酸输尿管支架管置于19只家犬输尿管内，每2周取出支架管在电镜下观察支架管材料结构的降解变化，并经凝胶渗透色谱仪测量支架管分子量变化。同时切取输尿管组织在光镜下观察输尿管组织病理改变。结果 支架管降解前分子量为68 900，第7周分子量降解为8 033，降解率达到88.3%。电镜下支架管表面的孔隙逐渐增多增大，材料不断被浸析降解。输尿管组织病理学变化主要表现为无菌性炎症。结论 消旋聚乳酸输尿管支架管具有良好的动物体内降解性能和组织相容性。 [关键词] 家犬；聚乳酸；降解；输尿管；支架管 [中图法分类号] [文献标志码] A Study on biodegradation of poly-DL-lactic acid ureteral stent in canine and pathological change of canine ureter Wang Wei1，Li Mu1，Liu Shaoqian1，Xu Huan2，Li Hong3 （1Department of Urology，Dongguan People’s Hospital, Dongguan, 523018,Guangdong Province;2Department of Pathology，3Department of Urology，West China Hospital, Sichuan University, Chengdu，610041,China） [Abstract] Objective To observe the degradation of poly-DL-lactic acid ureteral stent in canine and the pathological changes of canine ureter. Methods 19 stents were inserted into the canine ureters by operation. The degradation of poly-DL-lactic acid stent was checked under electronic microscope, and the change of molecular weight was measured by gel permeation chromatography every 2 weeks. Ureteral specimens were obtained from the ureteral incision, and stained with hematoxylin and eosin for light microscopy. Results The original molecular weight was 68 900, it was only 8 033 though degradation by the end of 7th week. The micro-pores in the stents increased in number and diameter during degradation. Traumatic inflammation was the main pathological change of canine ureter. Conclusion Poly-DL-lactic acid stent has good degradation property and tissue compatibility in vivo. [Key words] canine；poly-lactic acid；degradation；ureter；stent Corresponding author：Li Hong，Tel: 86-28E-mail：davidwung@163.com 聚乳酸（poly-lactic acid，PLA）在人体内可自然降解为二氧化碳和水，其中间产物乳酸也是正常