冠心病患者细胞色素P450 2C19基因多态性与接受药物 支架植入术后消化道出血的相关性研究-内科学专业论文.docxVIP

万方数据 万方数据 目 录 中 文 摘 要·························································································· ···············1 英 文 摘 要·························································································· ···············4 英 文 缩 写·························································································· ···············7 研究论文 冠心病患者细胞色素 P450 2C19 基因多态性与接受药物支架 植入术后消化道出血的相关性研究 前 言·························································································· ···············8 材 料 与 方 法·························································································· ·11 结 果·························································································· ·············18 附 图·························································································· ·············21 附 表·························································································· ·············25 讨 论·························································································· ·············31 结 论·························································································· ·············36 参 考 文 献·························································································· ······37 综述 CYP2C19 基 因 多 态 性 与 氯 吡 格 雷 代 谢 及 消 化 道 出 血 风 险 41 致 谢·························································································· ······················50 个 人 简 历·························································································· ··············51 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 冠心病患者细胞色素 P450 2C19 基因多态性与接受药物支架植 入术后消化道出血的相关性研究 摘 要 目的：本研究拟探讨细胞色素 P450 2C19（CYP2C19）*2、CYP2C19*3 基因多态性与药物洗脱支架植入术后接受阿司匹林与氯吡格雷双联抗血 小板的冠心病（coronary heart disease，CHD）患者的消化道出血的发生 是否具有相关性，有何相关性。分析 CYP2C19*2、*3 突变与氯吡格雷 代谢的关系，并探索接受双联抗血小板患者出现消化道出血的危险因素， 以指导经皮冠状动脉介入术（Percutaneous coronary interventions ，PCI） 植入药物洗脱支架后抗血小板药物的应用，减少术后接受双联抗血小板 患者消化道出血的发生。 方法：收集 2014 年 9 月 1 日至 2015 年 2 月 1 日收入唐