课件：结肠菌群与结肠肿瘤发生.pptVIP

The conclusions This new ?nding demonstrates that changes in gut microbiota controls metabolic endotoxemia, in?ammation,and associated disorders by a mechanism that could increase intestinal permeability. It would thus be useful to develop strategies for changing gut microbiota to control, intestinal permeability, metabolic endotoxemia, and associated disorders. 2019 - * 结肠菌群紊乱 炎症 肥胖 结肠肿瘤发生 ？ 2019 - * 炎症与肿瘤 约20%的肿瘤发生与炎症有关。 溃疡性结肠炎病史越长，癌变率越高。 炎症相关性结肠癌（colitis-assocated cancer CAC） 在经典的氧化偶氮甲烷（AOM）致癌动物模型中给予硫酸葡聚糖（DSS）可以显著增加结肠癌的发生率 。 炎症增加结肠癌的发病几率。 2019 - * The types and numbers of bacteria associated with biopsy samples were distinctly different for UC and CD patients. (B) CD patients; (C)UC patients. Bibiloni R, et al. The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn’s disease and ulcerative colitis patients. J Med Microbiol. 2006;55(Pt 8):1141-9. 2019 - * 机制 Mechanisms 两个主要机制(Vannucci et al.2009) 细菌感染后所产生的慢性炎症 细菌所产生的毒性代谢产物。 主要涉及的细胞及组织 mucosal cells, gut-associated lymphatic tissue [GALT], intraepithelial lymphocytes [IEL], dendritic cells [DC], and cells of the mesenteric lymph nodes [MLN]) 2019 - * (Vannucci et al.2009) 2019 - * Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility Uronis et al. conventionalized-IL10-/- mice Germ-free IL10-/- mice wild-type (WT) mice. IL10-/- mice mono-associated mice PLoS ONE, June 2009 | Volume 4 | Issue 6 | e6026 2019 - * 2019 - * 肠道微生物识别 microbial recognition 一些受体可感受细菌细胞壁、细胞核成分。 结直肠黏膜通过模式识别受体（pattern recognition receptors PRRs） Toll-like receptors ，TLRs；nucleotide-binding domain leucine-rich repeat proteins (NLR; also known as Nod-like receptors)；retinoic acid inducible gene-I like RNA helicases (RLH), C-type lectin receptors (CLR)。 研究最为深入和广泛的是TLRs。 2019 - * TLRs在细菌-炎症-肿瘤过程中起重要的介导作用  2019 - * 2019 - * The innate immune receptor Nod1 protects the intestine frominflammation-induced tumorigenesis Chen et al. Nod1 deficiency resu