益生菌和肠道粘膜免疫关系的研究进展-经济学家.PDF

※专题论述 食品科学 2007, Vol. 28, No. 08 537 王友湘，陈庆森 * (天津市食品生物技术重点实验室，天津商学院生物工程系，天津 300134) ：益生菌作为一种活的有机体能够在肠道内定植，维持肠道菌群平衡，能够刺激肠道免疫组织产生免疫球 蛋白、细胞因子，促进淋巴细胞的分化，对肠道粘膜免疫具有重要的影响。本文结合最近国内外的研究状况对益 生菌和肠粘膜免疫之间的关系作一下介绍，并提出了益生菌和肠道免疫方面在我国应开展的研究工作。 ：益生菌；肠道粘膜免疫；肠道微生物；细胞因子；免疫球蛋白 A ；淋巴细胞 Research Progress of Relationship between Probiotics and Intestinal Mucosal Immunization WANG You-xiang，CHEN Qing-sen* (Tianjin Key Laboratory of Food Biotechnology, Department of Bioengineering, Tianjin University of Commerce, Tianjin 300134, China) Abstract ：As one kind of living organisms, probiotics can live in the intestine and keep the intestinal microflora in balance, meanwhile they are able to stimulate the intestinal immune system and produce immunoglobulin and cytokine to promote differentiation of lymphocyte, thereby they are significance to the intestinal mucosal immunization. This article summarized the recent information at home and abroad to introduce the relationship between probiotics and the intestinal mucosal immunization, furthermore, it was pointed out the further research trend about probiotics and intestinal immunization in our country. Key words：probiotics；intestinal mucosal immunization；intestinal microflora；cytokine；SIgA；lymphocyte 中图分类号：R392.32 文献标识码：A 文章编号：1002-6630(2007)08-0537-06 肠道不仅是消化吸收的重要场所，也是生物体最大 的免疫器官。肠道粘膜面积庞大，它的结构和功能构 收稿日期：2007-03-28 *通讯作者 作者简介：王友湘(1981-)，女，硕士研究生，研究方向为发酵生物技术与生物活性物质。 测指标与《保健食品功能学评价程序和检验方法》中 [4] 王征. 急性毒性与遗传毒性体外高通量筛选方法的研究[D]. 上海: