miR-24对内皮细胞功能调节和其在心血管疾病发生发展中.PDF

生理学报Acta Physiologica Sinica , April 25, 2016, 68(2): 201–206 201 DOI: 10.13294/j.aps.2016.0026 综　述 miR-24对内皮细胞功能的调节及其在心血管疾病发生发展中 的作用 陈伟，欧和生* 广西医科大学药学院，南宁 530021 摘 要：microRNA-24 (miR-24)属于miR-23~27~24家族，高表达于血管内皮细胞(vascular endothelial cells, VECs) ，并调控 VECs多种特异性基因的表达。研究显示，miR-24参与VECs增殖、凋亡、血管形成、炎性反应和分化等功能的调节，而它的 表达异常与VECs功能紊乱及损伤密切相关，且参与心血管疾病的发生和发展。本文就miR-24参与调控VECs功能的分子机 制，及其在心血管疾病发生发展过程中的作用作一综述。 关键词：血管内皮细胞；miR-24 ；血管内皮细胞功能；心血管疾病 中图分类号：Q753 Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease * CHEN Wei, OU He-Sheng College of Pharmacy, Guangxi Medical University, Nanning 530021, China Abstract: microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease. Key words: vascular endothelial cell; miR-24; VECs function; cardiovascular disease microRNAs (miRNAs) 22 程的复杂调控网络。近年来资料表明，miRNAs 在 是内源性的长度在 个 核苷酸左右的RNAs ，通过降解靶基因mRNA 或抑 哺乳动物细胞分化、增殖和凋亡等生理过程中的表 制其翻译，从而影响动植物的基因调控过程。根据 达发生明显改变[1] ，参与糖尿病、癌症、心血管疾 miRNA-mRNA 结合的互补性，miRNAs 的调控机 病等人类重大疾病相关基因的表达调节[2] 。 制分为完全互补和部分互补，其机制决定了单一 随着研究深入，越来越多miRNAs 的功能及调 miRNA 可调控多个靶基因，单一靶基因可同时被 控机制被阐明，对血管内皮细胞(vascular endothelial 多个miRNAs 调控，由此构成了miRNAs 对生理过 cells, VECs) 功