AntimycobacterialDrugs（抗分枝杆菌药）培训课件.pptVIP

Pharmacokinetics Absorbtion: well absorbed after oral administration excretion: mainly through the liver into bile enterohepatic recirculation(肝肠循环) bulk excreted as a deacylated metabolite in feces a small amount in the urine. Distribution: widely in body fluids and tissues. relatively highly protein-bound adequate cerebrospinal fluid concentrations are achieved only in the presence of meningeal inflammation. Rifampin Clinical Uses MYCOBACTERIAL INFECTIONS Rifampin, usually 600 mg/d (10 mg/kg/d) orally, must be administered with isoniazid or other antituberculous drugs to patients wit