Membranepotential-北京大学医学部课程中心.pdf

离子通道和神经元的电活动 Ion Channels and Electric Activities of Neurons 王克威,神经生物学系/神经科学研究所 wangkw@ April 14 16, 2010 北京大学2009 －2010学年第2学期神经生物学课程（07’ undergraduates ） 上课地点、时间:逸夫楼508教室，8:00~11:00am and 13:30-16:30 Ion channels and neuronal excitability  The nervous system uses electrical signals Code, decode and process information  The electrical signals in the form of action potentials Action potentials within neurons Synaptic potentials between neurons Phrenic  Molecules for the electrical signals Motoneuron (red) Voltage-gated ion channels Serotonin (green) - Depolarize or hyperpolarize membrane Neurotransmitters - Ligand-gated ion channels or receptors Image courtesy of Gordon Mitchell and Brad Hodgeman Neuronal Coding Spatio-temporal pulse pattern Questions?  What is the information contained in such a spatio-temporal pattern of pulses? 这些排列的时-空电信号包涵什么样的信息？  What is the code used by the neurons to transmit that information? 神经元用什么样的编码来传递信息？  How might other neurons decode the signal?其他神经元如何解 码？  Can we read the code and understand the message of the neuronal activity pattern? 我们能否解读神经元的编码并懂得神 经元电活动形式的信息？  Do neuronal firings underlie learning and memory (even dreams) or newly synthesized proteins that carry different memories?神经元放电是否是学习与记忆的基础还是新合成的蛋白 质携带不同的记忆信息？  What is the molecular basis of short or long term memory?短 期或长期记忆的分子基础是什么？ Electrical signal or proteins?电信号还是蛋白质分子？ 本课概要Outline  神经元的电活动Electr