ACEI、ARB的临床应用体会.pptVIP

血管紧张素 II 的形成;异常的血管收缩 ;氧化应激;Willenheimer R et al. Eur Heart J. 1999;20:997?1008; Dahl?f B. J Hum Hypertens. 1995;9(suppl 5): S37?S44; Daugherty A et al. J Clin Invest. 2000;105:1605?1612; Fyhrquist F et al. J Hum Hypertens. 1995;9 (suppl 5): S19?S24; Booz GW et al. Heart Fail Rev. 1998;3:125?130; Beers MH et al. eds The Merck Manual of Diagnosis and Therapy. 17th ed. Whitehouse Station, NJ: Merck Research Laboratories. 1999: 1682?1704; Anderson S.Exp Nephrol. 1996;4(suppl 1):34?40; Fogo AB. Am J Kidney Dis. 2000;35:179?188.;RAAS激活时，AngⅡ促进氧化应激，抑制内皮细胞NO合成，促进炎症因子，粘附分子的释放，导致内皮功能紊乱，启动动脉粥样硬化和肾脏疾病的进