精氨酸脱敏牙膏治疗牙本质敏感的基础研究-第三军医大学学报.doc

精氨酸脱敏牙膏对牙本质小管封闭性能研究 李锐，周智*，陈娇 (重庆医科大学 口腔医院，重庆 400012 ) 摘要 目的：评价3种脱敏膏（高露洁专效抗过敏牙膏，舒适达原味牙膏，GC tooth mousse）对牙本质小管的封闭堵塞能力，为治疗牙本质敏感症提供参考。方法：新鲜拔出的完整无龋的第三磨牙制备40个牙本质小块，随机分为4组（n=10）,a：唾夜阴性对照组；b:GC tooth mousse组；c：舒适达组；d：高露洁组。治疗组牙本质小块采用同一规格牙刷分别用未经稀释约等量的膏浆早晚刷牙200下，其余时间浸泡于人唾液中，对照组直接置于人唾液中，持续10天。处理后样本置于扫描电镜下观察牙本质小管的封闭效果。结果： 3种牙膏对牙本质小管都有一定封闭作用，但每种膏浆的封闭能力有较大差异。结论：结果表明脱敏牙膏有封闭牙本质小管的能力，应用脱敏牙膏治疗牙本质敏感有一定的疗效，然而高露洁专效抗过敏牙膏对牙本质小管的封闭效果最佳。 关键词：牙本质敏感，脱敏牙膏，牙本质小管封闭性能 Effect of dentinal tubule occlusion by dentifrice containing 8% arginine LI Rui，Zhou Zhi*, Chen Jiao The affiliated hospital of stomatology, Chongqing medical university, Chongqing 400012, China Abstract Objectives: To evaluate the effectiveness on dentine surface pore structure and dentine morphology of three kinds of toothpastes. Methods: freshly extracted human third molar were collected at random and prepared 40 dentin discs .these dentin samples were divided 4 groups(n=10). The experimental treatment consisted of Colgate toothpaste containing arginine and calcium carbonate that was undiluted and applied on dentine surface for brushing 200 strokes, 2 times/day, and then soaked in degerming human saliva. A commercial toothpaste (the same undiluted solution) Sensodyne containing strontium chloride and a professional re-mineralizing treatment paste (GC Tooth Mousse diluted solution) were studied as comparison materials. The negative control group was soaked in degerming human saliva. The treatment processes were repeated 10 days. The occluding ability of the dentin tubules was evaluated using scanning electron microscopy (SEM).Results: the experimental treatment and the commercial sensodyne toothpaste significantly decreased tubules diameter and created smear layer on the dentine surface that reduced the diameter of dentinal tubules after treatment immediately. Conclusion: the application of the toothpaste containing arginine and calcium carbonate was determined to be effective on dentinal tubules diameter decrease and surface occ