S-腺苷高半胱氨酸甲基转移酶.pptVIP

下载本文档

11
0
约1.14万字
约 46页
2019-08-02 发布于天津
举报

S-腺苷高半胱氨酸甲基转移酶.ppt

下游靶基因生长调控信号转递代谢运输未知生长调控信号转递代谢运输未知饮食可调控下游靶基因总数被饮食调控数所有基因下游靶基因饮食主要调控被抑制的基因而不是激活的下游靶基因在水平下调前已经被饮食调控二号饮食一号表达倍数差下游靶基因在水平下调前已经被饮食调控病毒性致癌基因的同源基因转录因子的两个组成蛋白之一通常在癌症组织中无高表达为肝细胞存活所必须存活因子为肝癌起始所必须致癌因子抑制在酵母内的表达可被氨基酸调控人类的表观遗传高复杂性体现在智力使带有突变的病人不易正常结婚生子也就是抑制了突变的积累健康组织

* * 15 * Our work started with about 10years ago with the cloning of the RIZ gene. We were interested in studying Rb binding proteins. RIZ was cloned from a lamdaphage library using Rb protein as the probe. At the time we know very little about the function of this protein except we can recognize several interesting motifs. It has 8 zfs, a Rb binding motif, and a novel motif PR that is homologous to another protein in the database. The PR motif is now known to be homologous to histone lysine methyltransferases. So, RIZ is an Rb binding protein with potential histone methyltransferase func

您可能关注的文档

文档评论（0）

1亿VIP精品文档

更多 >

S-腺苷高半胱氨酸甲基转移酶.pptVIP