从指南看糖尿病规范化与个体化医学治疗的辩证统一.pptVIP

单药治疗时，HbA1c达到的降幅 HbA1c下降幅度 （%） 二甲双胍是单药降糖效果最好的口服药之一 Nathan DM, et al; ADA; EASD. Diabetes Care. 2009; 32(1): 193-203. * 即便是胰岛素促泌剂，刺激胰岛素分泌的作用也并不能持久 Holman RR, et al. Metabolism. 2006 May;55(5 Suppl 1):S2-5. Fig.3. Mean HOMA estimates of beta-cell function (%B) over the first 6 years from diagnosis of type 2 diabetes mellitus in nonoverweight and overweight patients allocated to, and remaining on, conventional (diet alone) of intensive (sulfonylurea or metformin [overweight subjects only]) monotherapies. * N Engl J Med. 2006 Dec 7;355(23):2427-43. ADOPT研究结果显示：胰岛素增敏剂维持血糖控制时间长于胰岛素促泌剂 Annualized s