李梨平-标记免疫检测技术新进展.pptVIP

* * These three subunits (α, βA, βB) are products of separate genes located on chromosomes 2 (α and βB subunit) and 7 (βA subunit) There is 23-27% amino acid homology between the α subunit and β subunit and 64% homology between the β subunits. Each subunit is initially assembled as a large pre-pro-protein which possess a N-terminal signal peptide (a pro-region needed for the accurate folding and dimerization of the subunits and which targets the polypeptide to the endoplasmic reticulum) and the mature C-terminal domain. Proteolytic partial cleavage of pro-region makes it biologically active. P