MTHFRC677T基因多态性与高同型半胱氨酸型高血压关联性研究.pdfVIP

·480 · ChinJ Dis Control Prev 　20 11　Jun;15(6) M T HF R C677T 基因多态性与高同型半胱 氨酸型高血压关联性研究 1 2 1 3 4 4 4 1 梁长流 , 蒋善群 , 彭少杰 , 陈常中, 张岩, 李建平, 霍勇, 徐希平 　　【】　　 (H )。 　 226 , N5, 10-(M T HF R)C677T (Hcy)。　(1)Hcy (P0.0 1);H (71.3%)(48.0 %)。 (2)T T CC+CT , Hcy , H 。(3)Hcy H Logistic , 、、Hcy (P0.05)。　M T HFR C677T H , 。 【】　;, ; 【】R18 1.1;R544.1　　　　　【】A 　　　　　【】1674-3679(2011)06-04 80-05 1 2 Associationstudy of MTHFR C677Tgenotype with H-type hypertension　L IANG Chang-iu , J IAN G Shan-qun , PEN G 1 3 4 4 4 1 Shao-jie , CHEN Chang-zhong , ZHA NG Yan , LI Jian-ping , H UO Yong , Xu Xi-ping .　1.Biomedical Institute, An- hui Medical University, Hef ei 　230032, China;2.School of Lif e Sciences, Anhui University, Hefei　230000, China; 3.Brigham and Women Hosp ital, Harvard University, Boston 　02115, USA;4.Dep artment of Cardiology, the irst Aff iliated Hosp ital of Peking University, Beijing 　1000 34, China 【Abstract】　Objective　T o ex p ore the impacts of genetic and environmenta f actors on H-type hyper tension risk in A nhui rura area.Methods　A tota of 226 patients of hy pertension from Anhui w ere se ected.C677T po ymorphism in M THF R gene and p asma homocysteine (Hcy)eve w ere detected.Results　(1)The average eve of Hcy in men w as sig- nif icant y hig her than that in w omen (P0.01);percentage of H-type hy pertension in ma e patients (71.3%)w as sig nif i- cant y higher than that in fema e patients (4 8.0 %).(2 )T he subjects w ith T T genoty pe had a significant y hig her average eve of Hcy and the risk of H-type hypertension t