阿托伐他汀内酯的波谱学数据与结构确证.pdfVIP

31 2 Vol. 31 No. 2 2014 6 Chinese Journal of Magnetic Resonance Jun. 2014 1000-4556(2014)02-268-10  450001 (UV)(IR)(MS) (1 1 1 13 H NMR)-( H- H COSY)( C NMR)DEPT (HSQC)(HMBC)NMR (NMR) O482.53 A (atorvastatin lactone, 1)(4R 6R)-6-{2-[2-(4-)-5- -3--4-()-1-]-2-}-4--2H--2- [1,2] . [3, 4] [3] 3 UV : 2013-05-07; : 2013-09-05 : (1970-)0371-mail kedi2009@126.com. * 2 269 1 13 IR H NMR C NMR (UV)(IR) 1 1 1 13 ( H NMR)-( H- H COSY)( C NMR)DEPT 1 13 (HSQC)(HMBC)(MS) H NMR C NMR IR MS 1 Fig.1 The structure of atorvastatin lactone 1 1.1 1.1.1 UV-2550Nicolet IS10 FT-IR 1 1 1 13 Nicolet KBr H NMRH- H COSY C NMR DEPTHSQC HMBC Bruker AV 400 Bruker 5 mm (VTU)296 K 1 13 DMSO-d6TMS H NMR C NMR 400.13 MHz 100.62 MHz1 13 H 90º 10.8 μs C 90º 6.5 μs 1 1 H- H COSY 5 330 Hz16 t t = 1 024512FT F F = 2 0481 024HSQC 2 1 2 1 13 1 C 24 038 HzH 5 330 Hzt t