asco2011结直肠癌更新.pptxVIP

ASCO 2011- Updates in Colorectal Cancer -Axel GrotheyProfessor of OncologyMayo Clinic RochesterNoteworthy at ASCO for CRC?No practice-changing information, but confirmation of standards of careEarly rectal cancer:Capecitabine can be used as radiosensitizer in neoadjuvant therapyAddition of oxaliplatin more toxic, no increase in pCR rateIs there a role for TNT (Total Neoadjuvant Therapy)?Noteworthy at ASCO for CRC?Early colon cancer:Value of oxaliplatin as adjuvant therapy in stage II cancers debatable Palliative therapy of CRC:IGF-R1 inhibitors conclusively ineffectiveNot all KRAS mutations ar