核磁共振分析软件spm_vbm(灰质计算)_使用手册.doc

VBM Tutorial John Ashburner March 15, 2010 1 Getting Started The data provided are a selection of T1-weighted scans from the freely available IXI dataset1. Note that the scans were acquired in the saggital orientation, but a matrix in the NIfTI headers encodes this information so SPM can treat them as axial. The overall plan will be to ? Start up SPM. ? Check that the images are in a suitable format (Check Reg and Display buttons). ? Segment the images, to identify grey and white matter (using the SPM→Tools→New Seg- ment option). Grey matter will eventually be warped to MNI space. This step also generates “imported” images, which will be used in the next step. ? Estimate the deformations that best align the images together by iteratively registering the imported images with their average (SPM→Tools→DARTEL Tools→Run DARTEL (create Templates)). ? Generate spatially normalised and smoothed Jacobian scaled grey matter images, using the deformations estimated in the previous step (SPM→Tools→DARTEL Tools→Normalise to MNI Space). ? Do some statistics on the smoothed images (Basic models, Estimate and Results options). The tutorial will use SPM8, which is is available from http://www.fil.ion.ucl.ac.uk/spm/. This is the most recent version of the SPM software2. Normally, the software would be downloaded and unpacked3, and the patches/?xes then downloaded and unpacked so that they overwrite the original release. SPM8 should be installed, so there is no need to download it now. SPM runs in the MATLAB package, which is worth learning how to program a little if you ever plan to do any imaging research. Start MATLAB, and type “editpath”. This will give you a window that allows you to tell MATLAB where to ?nd the SPM8 software. More advanced users could use the “path” command to do this. You may then wish to change to the directory where the example data are stored. SPM is started by typing “spm” or (eg) “spm pet”. This will pop open a bunch of windows. The top-left one is