（推荐精选）信号通路和肿瘤.pptVIP

* * * * * * Receptor Serine/Threonine Kinases (RSTKs) Typical example: Receptors for the TGF-? superfamily of ligands The TGF-? superfamily include 30 multifunctional proteins, e.g., activins, inhibins and the bone morphogenetic proteins (BMPs). 17 RSTKs isolated are in 2 subfamilies: type I and type II receptors. Nuclear proteins responding to TGF-? activation include c-Myc and Smad Ligands bind to the type II receptors Complexed with type I receptors Type II R phosphorylates type I receptor Initiation of signaling cascade * *