超滤法去除细菌内毒素.pdf

30 　5 　　　 Vol.30　No.5 2001 　9 JOURNAL OF HYGIENE RESEARCH Sep.　2001　315 :1000-8020 (2001)05-0315-02 ·· 王　铮　张惠新　戴海平 , 　300 160 :利用聚砜为膜材料, 通过相转化法制成外压式聚砜中空纤维 滤膜, 制成的中空纤维 滤器 (φ90mm×500mm), 水通量大于150 L h ·a m, 截留分子量在6000 左右, 可去除细菌内毒素, 达到药典规定的指 标。 文中介绍了热原本质、定量表示及测定方法;介绍了外压式中空纤维 滤装置在药液除热原工艺中的使 用情况, 并提出在运用时应注意的问题。 :细菌内毒素　中空纤维　 滤装置 :R197.39　　　　　　:B Study on the elimination of bacterial endotoxins by ultrafiltration device Wang Zheng, Zhang Huixin, Dai Haiping Membrane SCI TECH INST of Tianjin Poly echnic Universi y, Tianjin 　300160, China Abstract:An ex ernal-pressed polysulfone hollow fiber UF membrane, was made by phase inversion me hod.The cu - off molecular w eigh was 6000.The w a er permea ion ra e of his membrane module (φ90×500mm)is more han 150 L hr.a m.The opera ing resul s show ha he elimina ion of bac erial endo oxins by his membrane has reached he na ional s andard in pharmacopoeia, and his echnology is w or hy o be ex ended over o medical indu s ry .In addi ion, he essence of pyreo ogen, he quan ifica ion uni s and measure me hods for py reo ogen, and he opera ing condi ions of UF device in he process of elimina ing py reo ogen are in roduced.Some cri ical poin s in opera ion w as discussed. Key words:bac erial endo oxins, hollow fiber, ul rafil ra ion 　　, ();;;; , , 。 。 , ( 0.1 ～ 10 ), , 1　 , 5 ～ 100 。 “ 1　 ”, 、、、 , , , , , , ;, () , ( 1)。 , A。