血红蛋白变异体和糖化血红蛋白.pptVIP

血红蛋白病 血红蛋白变异体HbA1c 医学检验教研室·董骑 正常成人各血红蛋白组分百分比含量 (8Hb a96.5%97.5% 88 HbA22.5%-3.5% Hb F 0-2% 四种珠蛋白:α、β、V、δ 珠蛋白基因表达的时序性 器官9黄额肝脏 骨髓 9 DHbA 20 Hb A2 61218243036 121824303642 孕周或产前(周) 出生 产后(周) 血红蛋白病 概念 泛指所有因基因异常引起的血红蛋白异常的疾病 ●血红蛋白质或/和量的异常 ●地中海贫血(地贫}量的减少 Q-地贫 B地贫 地贫 6地贫 血红蛋白变异体-质的异常 血红蛋白病是一种遗传病 血红蛋白病数据库 Count of results I Total hemoglobin variant entries 1264 egories tries involving the alphal gene Entries involving the alpha2 gene ries involving the beta gene Entries involving the delta gene Entries involving the Agamma gene Entries involving the Gamma gene Entries with a fusion gene mutation Entries with a deletion mutation ntries with a substitution mutation 1382 Hemoglobins with high oxygen affinity 48 Unstable hemoglobin /hbvar/menu.html