材料导论 (58)材料导论.pdf

Video 8: Biomaterials for Drug Delivery System (Part II) In last lecture, we talked about what is drug delivery system and the significance of such systems. We also talked about diffusion controlled drug delivery systems, water penetration controlled drug delivery systems, and chemically controlled drug delivery systems. Today, I’d like to share with you some other drug delivery systems. 在上一讲中，我们讨论了什么是药物输送系统以及这些系统的重要性。 我 们还讨论了扩散控制药物输送系统，水渗透控制药物输送系统和化学控制药物输 送系统。 今天，我想和大家分享一些其他药物输送系统。 The drug delivery systems which respond to external stimuli such as temperature, pH, solvents, and ultrasound are called responsive delivery systems or smart delivery systems. 也就是外界刺激引起的释放。Depending on the type of stimuli and the nature of the polymer, the responses include hydration or dehydration, dissolution or precipitation, swelling or collapse, hydrophilicity or hydrophobicity, phase separation and degradation. 响应外部刺激（例如温度，pH，溶剂和超声）的药物递送系统被称为响应递 送系统或智能递送系统。 取决于刺激的类型和聚合物的性质，响应包括水合或 脱水，溶解或沉淀，溶胀或塌陷，亲水性或疏水性，相分离和降解。有缘学习 Temperature-responsive drug delivery systems include polymers 更多驾卫星ygd3076 which undergo physical changes due to changes in temperature. Poly(N- isopropyl acrylamide) (PNIPAM) is a commonly used temperature- sensitive polymer. The lower critical solution temperature (LCST 临界溶解 温度) of PNIPAM is 32 ° C. The polymer is soluble in aqueous solutions below the LCST. However, PNIPAM becomes insoluble when the temperature is increased above LCST. 温度响应性药物递送系统包括由于温度变化而发生物理变化的聚合物。 聚 （N-异丙基丙烯酰胺）（PNIPAM）是常用的温度敏感聚合物。 较低的临界溶解 温度（LCST）PNIPAM 的温度为 32℃。聚合物可溶于 LCST 以下的水溶液中。 但是，当温度升高到 LCST 以上时，PNIPAM 变得不溶。在这里我们可以理解为 PNIPAM 这个聚合物在 32 度以下是溶解的而在 32 度以上是不溶的。This behavior of PNIPAM is in contrast with most polymers where the solubility generally increases with an increase in temp