e09Circulat0rysystem循环系统文档.ppt

组织胚胎学课件 七年制英文医学班专用 中国医科大学 基础医学院 组胚 — 英文教学组 Chapter 9 Circulatory system ---Closed tubular system ---Blood circulatory or cardiovascular S ---Lymph vascular S The cardiovascular S heart artery vein capillary Organs: ---cavity organ: inner → outer layers ---parenchymal organ: capsule parenchyma: -cortex -medulla interstitia 1. Capillaries 1) LM : endothelium: basement membrane: pericyte: /flattened with processes /function: i. support ii. undifferentiated cell endothelial cell: processes – microvilli-like, finger-liked plasmalemmal vesicle /60-70nm, constitute about 25-35% of total volume /transendothelial channel /function: transport large molecules and storage of membrane( for enlarge, enlongated, pore-formed and microvilli) Weibel-Palade body: rod-liked, 3um long, 0.1- 0.3um in D, secrete factor VIII related antigen microtubule and microfilament EM : classification ① Continuous capillary : ---Structural feature: endothelial cell: -more plasmalemmal vesicles -tight junction basal lamina: complete ---Distribution: CT, MT, lung and CNS ② Fenestrated capillary ---Structural feature: endothelial cell: -have fenestrae or pore(60-80nm in D, with 4-6 nm diaphragm) basal lamina: complete ---Distribution: gastrointestinal tract, endocrine gland and renal glomerulus ③ Sinusoid capillaries ( enlarge capillary) ---Structural feature: endothelium: gap, pore basal lamina: incomplete or no( absent) ---Distribution: liver, spleen and bone marrow 3) Function : a. Selected permeability and exchange of material b. Synthesis(F VIII Rag, endothelin, ET and PGI 2 ) and metabolism(angiotensin I→angiotensin II) activity c. Anti-blood coagulate 2. Artery ---large A: aorta, pulmonary trunk ---medium-sized A: all named A, the