神经精神药理英文课件：DRUG TREATMENT OF PSYCHOSIS.pptVIP

Contribution of CYP450 in atypical antipsychotic drug metabolism Drug CYP450 1A2 2C9/2C19 2D6 3A4 Aripiprazole ? ? ? ? Clozapine ? ? ? ? Olanzapine ? ? ? ? /- Paliperidone ?/- Quetiapine ? ? ? Risperidone ? ? ? ? Ziprasidone ? (1/3 with aldehyde oxidase) Enzyme Substrate Inhibitor Inducer CYP1A2 Clozapine, olanzapine Fluvoxamine, ciprofloxacin Carbamazepine, smoking CYP2C19 Fluoxetine, fluvoxamine Carbamazepine, phenytoin CYP2D6 Aripiprazole, clozapine, olanzapine, risperidone, conventional antipsychotics Bupropion, fluoxetine, paroxetine, duloxetine CYP3A4 Aripiprazole, clozapine,