神经生物学：基底神经节疾病.pptVIP

Fig. 6. The neurotoxins used in animal models of PD induce mitochondrial dysfunction. MPTP is converted by monoamine oxidase B (MAO B) to MPP+. Like 6-OHDA, MPP+ is taken up by dopamine transporters and then can be accumulated by mitochondria, leading to complex I inhibition. In contrast to 6-OHDA, MPP+ can be taken up by vesicular monoamine transporters, which reduces the toxicity of MPP+. Paraquat and rotenone also inhibit mitochondrial complex I, whereas maneb inhibits the mitochondrial complex III. * Seed for LB * Fig. 1. Overview of the a-syn aggregation process integrated with the oxidat