癌生物学课件：Tumor invaison and metastasis.pptxVIP

Tumor invasion and metastasis: a question of life or death;Outline of the lecture ;Outline of the lecture ;Cancer is a major public health problem worldwide;Sethi N, et al. Nat Rev Cancer, 2011; 11:735-48;Sethi N, et al. Nat Rev Cancer, 2011; 11:735-48;Cancer Statistics, 2015;Tumor metastasis: responsible for over 90% of mortality from cancer;Routes of metastasis: lymphatic and/or blood vessels ;Metastatic patterns of ovarian cancer;Evolution of tumor metastasis;Fidler IJ. Nat Rev Cancer, 2003; 3: 453-8;Concept 1: Inefficiency of the invasion-metastasis cascade;Schroeder A, et al. Nat Rev Can