乳腺癌内科治疗关键关注点.ppt

;内 容;乳腺癌的分子分型;激素反应型 病情发展相对缓慢---内分泌治疗 HER2过表达型 病情发展比较快-----分子靶向药物治疗 三阴型 病情复杂-----------化疗为主;Surrogate definitions of intrinsic subtypes of breast cancer;Systemic treatment recommendations for subtypes ;Overexpression of HER2 is associated with poor prognosis;全身辅助治疗;HR+/HER2+;HR+/HER2-;HR-/HER2+;Adjuvant trastuzumab has a substantial evidence base with 13,000 patients treated in 4 major trials;;1.0;Eligibility: Her2+ LABC/MBC PD on prior Trastuzumab 1 prior CT for MBC Normal LVEF;;HT 赫赛汀 8mg/kg (起始剂量), day 16mg/kg, days 1, q3w 多西紫杉醇 100mg/m2, day 1 ;曲妥珠单抗+多西紫杉醇±希罗达