代谢综合征与乳腺癌.docVIP

代谢综合征与乳腺癌 杨郁 李昌臣 摘要 大量研究显示，代谢综合征及其各组份可能增加女性乳腺癌的患病风险，在绝经后妇女中表现尤为明显。这种作用可能通过胰岛素抵抗影响雌激素和性激素结合球蛋白水平、高胰岛素血症的直接或间接作用以及脂肪因子水平异常等机制实现。因此，对于我国乳腺癌发病率可能随代谢综合征人群不断扩大而上升的趋势应予以足够重视。 Abstract There is growing epidemiological data to suggest that metabolic syndrome and its components increase the incidence of breast cancer, especially in postmenopausal women, mechanisms such as changes of estrogens and sex hormone binding globulin(SHBG) concentration, direct or indirect action of hyperinsulinemia, abnormal levels of adipocytokines may account for this association. Thus, m