绿色化学 英文sciencedirect文献.docxVIP

European Journal of Medicinal Chemistry 46 (2011) 297e 306 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry j o u r n a l h o m e p a g e : h t t p : / / w w w . e ls e v i e r . c o m / l o c a t e / e j m e c h Original article One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones Constantinos G. Neochoritis a, Tryfon Zarganes-Tzitzikas a, Constantinos A. Tsoleridis a, *, Julia Stephanidou-Stephanatou a, *, Christos A. Kontogiorgis b, Dimitra J. Hadjipavlou-Litina b, Theodora Choli-Papadopoulou c Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54124, Macedonia, Greece Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece a r t i c l e i n f o Article history: Received 4 June 2010 Received in revised form 29 October 2010 Accepted 11 November 2010 Available online 19 November 2010 Keywords: 2-Aminobenzimidazole Acetophenones Cytotoxicity E/Z configuration of imines Green chemistry Lipid peroxidation inhibition Lipoxygenase inhibition Microwave irradiation Pyrimido[1,2-a]benzimidazoles  a b s t r a c t The synthesis of a number of benzimidazole Schiff bases 3 and 3-oxo-pyrimido[1,2-a]benzimidazoles 4 in excellent yields by a one-step sequence from the reaction of 2-aminobenzimidazole under green chem-istry conditions is described. Structural assignments of the new compounds as well as complete assign-ment of 1H and 13C NMR signals have been unambiguously achieved based on the analysis of their 1H and 13C NMR (1D and 2D), IR, MS and elemental analysis data. To the synthesized Schiff ba