细胞信号通路ppt细胞信号通路大全上下细胞信号通路ppt ip3_pathway.ppt

GP C R C N IP3 Pathway CD19 Ag Iga Iga Igb Igb LAT TCR-CD3 Complex Growth Factor Receptor CaCnComplex MEF2 p300 CREB CBP GrowthFactors Gene Expression NFAT I P 3 R Ca2+ Ga Gb Gg Gb Gg Ga-Q GTP GDP BTK PLCg PIP3 PIP2 PLC IP3 PTEN BCR PMR1 PLCb2 ITK4 Vav PI3K PLCg1 SYK Ca2+ Ca2+ GADS Fyb SOS SLP76 GRB2 SHC Fyn GTP HRas ZAP70 PLCg PLCe PLCg Ca2+ Calm CaMKK CaMKII CaMKIV HDAC9 Caln 2009 ProteinL C * Review: IP3 (Inositol 1,4,5-triphosphate), also known as a second messenger, is a molecule that functions to transfer a chemical signal received by the cell, such as from a hormone, neurotransmitters, growth factors and hypertrophic stimuli such as AngII (Angiotensin-II), Beta-adrenergic receptor agonists, and ET1 (Endothelin-1) to various signaling networks within the cell. IP3 is known to play a crucial role in initiating and propagating these messages; however, the precise mechanism of how IP3 relates to the next element in its signaling pathway, the calcium wave, remains highly controversial. The receptors for IP3, IP3R (IP3 Receptor) constitute a family of Ca2+ channels responsible for the mobilization of intracellular Ca2+ stores. Three different receptor types have been molecularly cloned, and their genes have been classified into a family. IP3Rs are tetramers that act as ligand-gated channels facilitating Ca2+ release from internal stores/endoplasmic reticulum. The primary structure of the IP3R contains 3 domains: an Inositol triphosphate binding domain near the N terminus, a coupling domain in the middle of the molecule, and a transmembrane spanning domain near the C terminus (Ref.1). Two essential signaling pathways involve the intracellular generation of Inositol Phosphates. The first signaling pathway is initiated by PLC (Phospholipase-C). PLC are soluble proteins that are partly cytosolic and partly associated with membrane. Based on their functional and structural characteristics, they have been grouped into four classes: PLC-Delta, -Beta, -Ga