遗传chapter6-8多态性与突变-1.pptVIP

Chapter 6 Genetic Variation in Individuals: Mutation and Polymorphism 王小竹 Wang Xiaozhu 2012-03-21 Genome Mutations Chromosome Mutations Types of gene mutations Nucleotide substitutions Deletions and insertions MUTATION(1)Nucleotide substitutions ① Missense mutations ② Nonsense mutations ③ RNA processing mutations Large deletion _ Detection for TSC2 Effects of Recombination Recombination in Hemophilia A Dynamic Mutations Concept: mutations in disorders involve amplification of trinucleotide repeat sequences. Nonmendelian