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Plasma cell Plasma cell Mast cell Mast cell Location : near small BV Granules: membrane coated, big, abundant, heterogeneous, basophilic, water soluble, metachromatic (metachromasia: change color of applied dye) IgE – R on membrane Secretions of mast cell vasoactive subtances inflamative mediators in granule (stored, immediate releasing) Histamine, E/N-chemotactors, Heparin out of granule (new synthesized, delayed) Proteases (chymase / tryptase), Leukotriene（白三烯）-C4(SRS), TGF-β, ILs, PGd2 Degranulation of mast cell - leads to allergic / inflammative reactions *Ag – IgER – aggregated R – Calcium increase – synthesis & MT movement – exocytosis leads to : smooth muscle constraction, glandular secretion, BV dilation and being more permeable, leukocytes migrating Asthma, Hives(荨麻疹）, Drug rash, Allergic shock, Intestinal cramps(痉挛）... Stem cells in mature tissue Usually attached to small blood vessels eg. Pericyte (cap), adventitial cells (venule) Can differentiated into fibroblast, hematopoietic cell , mast cell, fat cell, endothelia, mesothelia, osteoblast, chondroblast… Undifferentiated mesenchymal cells Key points 1.structure and functions of macrophage,mast cell and plasma cell 2. molecules and their functions in ground substance 3.conclusion of protein synthesizing and secreting cells Thanks Extracellular events Synthesizing cells of collagen EM of fibrils in cross and longitudinal sections show regular alternative dark and light bands -cross striations. Elastic fiber HE: light pink Fresh :
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