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资料课件说明内科学leukemia.pptx

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LEUKEMIA;Female, age 47 years, was admitted to hospital for feeling weak and subcutaneous bleeding for 1 week. Blood test: WBC 54×109/L, HGB 72g/L, PLT 15×109/L. Bone marrow aspiration: blasts 42%, MPO (-), CD19 (+), CD20 (+) Question: 1. What’s the initial diagnosis of this patient and the evidences? 2. What’s the principle of treatment?;CONTENTS;Origin: Hematopoietic system Level: Malignant clonal disease of stem cell Nature: Malignancy;Concept of leukemia;1. Maturity of the leukemia cells 2. Kinds of cells 3. The number of WBC 4. FAB classification 5. MICM classification (WHO);According to the maturity of the leukemia cells;Relationship between AL and CL;Acute Lymphocytic/Lymphoblastic Leukemia(ALL) : most common type in young children; also affects adults, 65 Acute Myelogenous/ Myeloid Leukemia(AML) more common in adults than in children. Chronic Lymphocytic leukemia (CLL) most often affects adults over the age of 55 Chronic Myelogenous leukemia (CML) occurs mainly in adults;Leukocytosis：WBC10×109/L (Leukocyte Leukemia ) Non-leukocytosis ：WBC＜1×109/L (Non-leukocyte Leukemia ) ;In 1976, seven hematology experts come from France, America, Britain (Franch-American-British) proposed the classification of acute Leukemia in Paris, then amended many times. AML(ANLL) ALL;M0 Minimally differentiated AML M1 AML without maturation M2 AML with maturation M3 Acute promyelocytic leukemia (APL) M4 Acute myelomonocytic leukemia (AMML) M5 Acute monocytic leukemia (AMoL) M6 Erythroleukemia (EL) M7 Acute megakaryoblastic leukemia (AMeL);M0 Minimally differentiated AML;M4 Acute myelomonocytic leukemia (AMML);M6 Erythroleukemia (EL);; The FAB category of ALL; Morphology Immunology Cytogenetics Molecular biology;WHO Classification of AML;WHO Classification of Lymphoproliferative Syndromes;Virus Ionizing Radiation Chemicals and drugs Genetic O