慢性移植物抗宿主病.pptVIP

内 容 Update of knowledges in cGVHD Progress in pathophysiology of cGVHD Treatment for cGVHD Novel therapeutic strategies of cGVHD cGVHD的病理生理学 Thymic damage and defective negative selection Deficiency of T-regs TGF-β and PDGF pathways mediated fibrosis Th1/Th2/Th17 paradigm cytokine Dysregulated B-cell and humoral immunity Takanori Teshima, ASBMT 2008 The 5 Tenets of cGVHD 中央免疫耐受：胸腺损害学说 外周免疫耐受：T-regs细胞缺陷 T-regs play a critical role in peripheral tolerance and development of cGVHD CD4+ lymphopenia is a key factor in Treg homeostasis, and impaired reconstitution of Tregs can result in loss of t