内皮细胞在血液循环及炎症反应中的作用_贺雅婷.pdfVIP

中国城乡企业卫生2019年4月第4期（总第210期） ·综 述 · 内皮细胞在血液循环及炎症反应中的作用 贺雅婷，刘海杰，马晓峰 天津医科大学总医院神经内科，天津 300052 摘要：通过回顾近期国内外文献，探讨内皮细胞在血液循环及炎症反应中的作用。内皮细胞广泛分布于血管壁，可以通 过分泌多种抗凝和促凝因子，在抗凝和促凝平衡过程中发挥重要的调节作用。内皮细胞还可以影响血管通透性。内皮细 胞也可通过内皮舒张因子、内皮超极化因子和内皮收缩因子对血管的收缩和舒张进行调节。内皮细胞亦可与白细胞发 生黏附，发生间质和实质细胞水肿、出血及炎症反应等黏附连锁反应。本文对内皮细胞在促凝血、血管壁通透性、血管舒 张与收缩及炎症反应等方面的作用进行了归纳总结，为临床疾病的研究提供理论基础，为疾病的治疗提供新策略。 关键词：内皮细胞；血液循环；炎症反应 中图分类号：R543 文献标识码：A 文章编号：1003-5052 （2019）04-028-04 DOI:10.16286/j.1003-5052.2019.04.011 Role of endothelial cells in blood circulation and inflammatory responses HE Ya-ting, LIU Hai-jie, MA Xiao-feng Department of Neurology, General Hospital of Tianjin Medical University, Tianjin 300052, China Abstract: The role of endothelial cells in blood circulation and inflammatory response was studied by reviewing recent literatures. Endothelial cells are widely distributed in the blood vessel wall and can be involved in the regulation of pro-coagulation and anti-coagulation balance by secreting a variety of mediators. The production and release of anti-coagulation and pro-coagulation factors play an important role in the regulation of pro-coagulation and anti-coagulation balance. Endothelial cells can also affect the permeability of vascular. Endothelial cells can also regulate the contraction and dilation of blood vessels via endothelium derived relaxing factor, endothelium derived hyperpolarizing factor and endothelium derived contracting factor. Endothelial cells can also adhere to leukocytes and cause edema, hemorrhage, inflammatory reactions. In this review, the role of endothelial cells in regulating coagulation, permeability of vessel, vas