肿瘤分子生物学细胞永生化和肿瘤发生.pptVIP

XI’AN JIAOTONG UNIVERSITY 肿瘤分子生物学细胞永生化和肿瘤发生 Page * 肿瘤概念 Cancer is a genetic disease, arising from an accumulation of mutations that promote clonal selection of cells with increasingly aggressive behavior. The vast majority of mutations in cancer are somatic and are found only in an individuals cancer cells. However, about 1% of all cancers arise in individuals with an unmistakable hereditary cancer syndrome. These individuals carry a particular germline mutation in every cell of their body. Science Vol. 278. no. 5340, pp. 1043 – 1050, 7 November 1997 在基因水平上失去对其生长的