人际社会的幕后导演avpr1a.pptxVIP

人际社会的幕后导演 ——揭开AVPR1A基因的神秘面纱《分子进化》期末报告 生物信息学 062938 蔡霄鹏 指导教师：张晓艳Playboy?AVPR1A?Mc Dreamy?AVP：精氨酸垂体后叶加压素AVPR1AAVP蛋白AVP蛋白受体AVP受体基因AVPR1BAVPR2G蛋白耦联受体EvolutionThe Gist of the report AVP receptor genes and proteins AVPR1A revealed by molecular resources AVPR1A associated with social brainⅠ.AVP receptor genes and proteinsProtein Gene familyG蛋白耦联受体蛋白超家族 （G-protein-coupled receptors, GPCRs） （seven-transmembrane domain receptors, 7 TM receptors） G蛋白耦联受体多基因家族 （GPCRs multi-gene family）AVP proteinAVP（Arginine vasopressin） 精氨酸后叶加压素ADH（antidiuretic hormone） 精氨酸抗利尿激素 /wiki/File:Arginine_vasopressin3d.pngAVP ReceptorsTypeSecond messengerLocationsActionsV1aPhosphatidylinositol/calciumLiver;Kidney;Peripheral vasculature;Brain;Vasoconstriction; platelet aggregation; gluconeogenesis; Release of factor VIII and von Willebrand factor; Social recognitionV1bPhosphatidylinositol/calciumPituitary gland;Brain;Adrenocorticotropic hormone secretion in response to stress; Social interpretation of olfactory cuesV2Adenylate cyclase/cAMPBasolateral membrane of the cells lining the collecting ducts of the kidneysAllows water to be reabsorbed down an osmotic gradient, and so the urine is more concentrated; Release of von Willebrand factor and surface expression of P-selectin through exocytosis of Weibel-Palade bodies from endothelial cellsAVP receptor genesGene typePhysical locationAVPR1AAVPR1BAVPR2AVP receptor genesGene typeGenomic context AVPR1AAVPR1BAVPR2Homology of genesHomology of proteinsHomology of AVPR1A/1B/2Ⅱ.AVPR1A revealed bymolecular resourcesAVPR1A gene遗传定位：12q14-15物理定位码方向：3’ — 5’包含于一段6.4-kb 长度的EcoR1片段两段分别编码的外显子 中间由一段内含子隔开AVPR1A gene in SNP DBAVPR1A gene ontologyOrthology of AVPR1A genesAVPR1A protein AVPR1A蛋白一种 麦芽糖结合蛋白( Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor ) PDB e-Entry为1ytv /pdb/explore/explore.do?structureId=1YTVAVPR1A protein/uniprot/P37288AVPR1A protein conformation 麦芽糖结合外周蛋白 Maltose-binding periplasmic