原发性肝细胞癌HBsAgFas和PCNA抗原的表达及其意义.doc

原发性肝细胞癌HBsAgFas和PCNA抗原的表达及其意义 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：原发性肝细胞癌HBsAgFas和PCNA抗原的表达及其意义 1 1 材料与方法 3 2 结 果 4 3 讨 论 6 文2：卵巢上皮性癌PTEN和PCNA的表达 7 1材料和方法 7 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 原发性肝细胞癌HBsAgFas和PCNA抗原的表达及其意义 文1：原发性肝细胞癌HBsAgFas和PCNA抗原的表达及其意义 Expression of HBsAg，Fas and PCNA in hepatocellular carcinoma and their significance in undetanding HBV related hepatocarcinogenesis 【ABSTRACT】Objective:To investigate the expressive characte and their significance by detecting the expressio of HBsAg，Fas and proliferating cell nuclear antigen(PCNA) in both hepatocellular carcinoma(HCC) and their surrounding noncancerous correlation between HBV infection and HCC，and the possible mechanism of hepatocellular carcinogenesis were :HBsAg，Fas and PCNA were detected by immunohistochemistry from 52 cases of hepatocellular carcinoma as well as 42 corresponding noncancerous data suchas serum AFP levels was also :Both HBsAg and Fas were strongly expressed in noncancerous tissues，with positive rate of each achieving %.However their expression rates in cancer tissues were % and % respectively，significantly lower and less inteive than that of their corresponding noncancerous ones(P＜).The expression in cancer tissues are only found in the well differentiated correlatio were found for HBsAg and Fas expressio in both cancer and noncancerous average PCNA labeling index(PCNA LI)of HCC was ±，significantly higher than that of noncancerous tissues，which is only ±(P＜).Whereas among HCC patients，the average PCNA LI of HBsAg positive ones was significantly lower than that of HBsAg negative ones(± vs ± P＜).In noncancerous tissues most PCNA positive cells are nucleus ovalshaped small cells which are mostly found in the perilobule :As well differentiated HCC cells possess the ability to express HBsAg，the much less expression of HBsAg in cancer tissues was postulated to be the result of undifferentiation of cancer close relatiohip between HBsAg and Fa