浙江大学《遗传学》课件-chapter4 Genetic Variation in Population.pptVIP

Heterozygote Advantage Gene Homozygote Phenotype Heterozygote Advantage Alternative Explanations CFTR Cystic fibrosis Increased resistance to cholera CFTR mutant alleles appeared before Cholera epidemics; increased resistance to typhoid and/or asthma. HLA (MHC) Highly polymorphic Enhancing resistance to infectious disease The loci too polymorphic to be accounted for by heterozygote advantage; may have other benefits. TDS Tay-Sachs mainly in Ashkenazi Jews Resistance to TB The high frequency of disease can be explained by founder effect and genetic drift Sickle Cell Anemia in West Africa A/A