Agilent Reducing HPLC Solvent Consumption - Combating the worldwide shortage of acetonitrile by deploying short LC columns with small internal diameters and particles 说明书用户手册.PDF

Reducing HPLC Solvent Consumption Combating the worldwide shortage of acetonitrile by deploying short LC columns with small internal diameters and particles Technical Note 600 500 85 % reduction in solvent consumption 400 300 200 100 0 0.1 0.2 0.3 0.4 0.5 0.6 Introduction Towards the end of 2008 the deterioration of the global economy led to a worldwide shortage of acetonitrile – a solvent used extensively as a mobile phase component in HPLC analysis. In January 2009 the price of acetonitrile was recorded at about 100 US$ per liter with disposal costs about double this price. The immediate chal- lenge for analytical laboratories is to reduce their consumption of this HPLC solvent as much as possible. The degree to which each laboratory is able to reduce ace- tonitrile consumption depends on the individual operating environment. Regulated laboratories that work with validated methods have less flexibility to change these methods and thereby have less opportunity to reduce solvent consumption. Different strategies must be followed than in non-regulated environments, in which the opportunity to reduce solvent consumption is must greater. Overview Dimension USP EP Length ± 70 % ± 70 % The Agilent portfolio of LC equipment, Internal diameter ± 25 % ± 25 % including the 1120 Compact LC, 1200 Particle size 50 % smaller, not larger 50 % smaller, not larger Series HPLC and 1200 Se