生殖道B族链球菌定植与早产的相关性研究.docxVIP

生殖道B族链球菌定植与早产的相关性研究 　　[摘要]目的探討妊娠期生殖道b族链球菌（groupbstreptococcus，gbs）定植与早产的相关性。方法选取2017年7月～2018年10月期间于本院接受正规产前检查及住院保胎的28～36+6周有早产倾向的单胎孕妇500例，采用实时聚合酶链反应（polymerasechainreaction，pcr）技术检测，比较gbs定植阳性组与阴性组母婴妊娠结局，并分析gbs定植与早产的关系。结果与gbs定植阴性组比较，gbs定植阳性组胎膜早破（16.50%vs29.55%）、早产（5.58%vs13.64%）、绒毛膜羊膜炎（1.94%vs35.23%）、产后出血（2.43%vs9.09%）及新生儿肺炎（0.97%vs10.23%）发生率明显增加，差异均有统计学意义（p0.01）。logistic回归分析结果表明，gbs定植阳性是早产的危险因素（or=2.23，95%ci：1.34～3.41，p0.05）。结论生殖道gbs定植可导致母婴不良结局，且gbs定植是早产的危险因素。 　　[关键词]b族链球菌;早产;妊娠结局 　　[中图分类号]r446.5[文献标识码]b[文章编号]1673-9701（2019）35-0065-04 　　correlationbetweencolonizationofgroupbstreptococcusingenitaltractandprematuredelivery 　　zhangyuehuizhengjianqiongwangyepingchenhaiyingzhanghongping 　　departmentofobstetricsandgynecology，wenzhoupeopleshospitalinzhejiangprovince，wenzhou325000，china 　　[abstract]objectivetoinvestigatetherelationshipbetweencolonizationofgroupbstreptococcus（gbs）ingenitaltractduringpregnancyandprematuredelivery.methodsatotalof500single-fetuspregnantwomenwithprematurebirthtendencyfor28to36+6weekswhoreceivedregularprenatalexaminationandwerehospitalizedinourhospitalforpreventingmiscarriagefromjuly2017tooctober2018wereselected.real-timepolymerasechainreaction（pcr）techniquewasusedfordetection.thematernalandfetalpregnancyoutcomesbetweenthegbscolonizationpositivegroupandthenegativegroupwerecompared.andtherelationshipbetweengbscolonizationandpretermbirthwasanalyzed.resultscomparedwiththatofthegbscolonization-negativegroup，theincidenceofprematureruptureofmembranes（16.50%vs29.55%），prematuredelivery（5.58%vs13.64%），chorioamnionitis（1.94%vs35.23%），postpartumhemorrhage（2.43%vs9.09%）andneonatalpneumonia（0.97%vs10.23%）ingbscolonization-positivegroupincreasedsignificantly，andthedifferencewasstatisticallysignificant（p0.01）.logisticregressionanalysisshowedthatgbscolonizationpositionwasariskfactorforpretermbirth（or=2.23，95%ci：1.34-3.41，p0.05）.conclusiongbscolonizationofthereproductivetractcanleadtoadverseoutcomesinmothersandinfants，andgbscolonizatio