花青素对神经退行性疾病的作用_张挺.pdfVIP

生命的化学, 2022, 42(9): 1635-1642 doi: 10.13488/j.smhx 花青素对神经退行性疾病的作用 1 1 1 1 2 2 1 1* 张挺 ，李冀宏 ，周浩楠 ， 闫洪旭，姜学涛 ，张如云， 贾若丹，彭亚会 1 2 ( 哈尔滨医科大学基础医学院，哈尔滨 150081；哈尔滨医科大学药学院，哈尔滨 150081) 摘要：神经退行性疾病以大脑或脊髓特定区域神经元死亡为特征，包括阿尔茨海默病、帕金森病和肌 萎缩性侧索硬化症等疾病。氧化和亚硝化应激、兴奋性毒性、内质网应激、蛋白质聚集和神经炎症可 促进神经退行性过程。花青素是类黄酮化合物，可以调节神经元死亡的几种因素，其代谢物生物利用 度更高。本文将简述花青素的结构和分类，并综合体外实验、动物模型和人群实验，对花青素的吸收 和血脑屏障通透性、抗氧化性、抗神经炎作用以及调节蛋白稳态展开介绍，以此探讨评估花青素对神 经退行性疾病的神经保护和治疗潜力。 关键词：花青素；酚酸；黄酮；氧化应激；炎症；神经保护 Effect of anthocyanins on neurodegenerative diseases 1 1 1 1 2 2 ZHANG Ting , LI Jihong , ZHOU Haonan , YAN Hongxu , JIANG Xuetao , ZHANG Ruyun , JIA Ruodan1, PENG Yahui1* 1 ( School of Basic Medicine, Harbin Medical University, Harbin 150081,China; 2School of Pharmacy, Harbin Medical University, Harbin 150081,China) Abstract: Neurodegenerative diseases are characterized by neuronal death in specific areas of the brain or spinal cord, including Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis. Oxidative andnitrosative stress,excitotoxicity,endoplasmicreticulum stress,protein aggregationandneuroinflammation canpromote neurodegenerative processes. Anthocyanins are flavonoids,which can regulate several factors of neuronal death, and their metabolites have higher bioavailability.This paper will introduce the four effects of anthocyanins and their metabolites on blood-brain barrier permeability, antioxidation, anti-neuritis and regulating protein homeostasis, to explore the evidence to evaluate the