2011-12-加拿大-阵列基因组杂交技术在加拿大产前诊断中的应用.pdfVIP

SOGC–CCMG JOINT TECHNICAL UPDATE No. 270, December 2011 Use of Array Genomic Hybridization Technology in Prenatal Diagnosis in Canada Abstract This technical update has been prepared by the Genetics Committee of the Society of Obstetricians and Objective: To summarize for obstetrical care providers the current Gynaecologists of Canada (SOGC) and the Prenatal literature on array genomic hybridization in prenatal diagnosis Diagnosis Committee of the of the Canadian College of and to outline the recommendations of the Canadian College of Medical Geneticists (CCMG) and approved by the Executive Medical Geneticists regarding the use of this new technology with of the SOGC. respect to prenatal diagnosis . PRINCIPAL AUTHORS Evidence: PubMed and Medline were searched for articles published Alessandra Duncan, PhD, Montreal QC in English between 2004 and 2010, using the key words DNA Sylvie Langlois, MD, Vancouver BC QF-PCR, quantitative fluorescent polymerase chain reaction, fetal SOGC GENETICS COMMITTEE chromosomal abnormalities, prenatal diagnosis, array genomic hybridization, fetal structural anomalies, and copy number variants . R . Douglas Wilson, MD (Chair), Calgary AB