Flovagatran-TGN-255-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Flovagatran Cat. No.: HY-10270 CAS No.: 871576-03-3 Synonyms: TGN 255 分⼦式: C₂₇H₃₆BN₃O₇ 分⼦量: 525.4 作⽤靶点: Thrombin 作⽤通路: Metabolic Enzyme/Protease 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Flovagatran (TGN 255) 是⼀种有效的、可逆的凝⾎酶 (thrombin) 抑制剂 (Ki: 9 nM)。Flovagatran 可⽤于动脉 和静脉⾎栓形成的研究。 体内研究 Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs [1]. Animal Model: Chicks [1] Dosage: 1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes. 2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes. 5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes. Administration: Bolus plus infusion Result: Elevated PD markers, and produced minimal post-operative blood loss. REFERENCES [1]. Nelson DA, et al. Pharmacodynamic and effi