勃起功能障碍治疗进展详解演示文稿.pptVIP

磷酸二酯酶5抑制剂治疗男性勃起功能障碍的机理 当前第30页\共有82页\编于星期五\18点 cGMP specific protein kinase NO Guanylyl cyclase GTP cGMP K+ Ca2+ Decreased Ca2+ Smooth muscle relaxation 5GMP PDE5 PDE5 Inhibitor Cavernous nerve Endothelial cell NO L-Arginine Oxygen Nonadrenergic Noncholinergic Sexual Stimulation Smooth muscle cell 当前第31页\共有82页\编于星期五\18点 三种磷酸二酯酶5抑制剂的分子结构式 Sildenafil Vardenafil tadalafil N H N N O O C H 3 O O H H N H N N N C H 3 O S N N O O C H 3 C H 3 N H N N N C H 3 O O C H 3 S N N C H 3 O O C H 3 O C H 3 当前第32页\共有82页\编于星期五\18点 Sildenafil, vardenafil and tadalafil对 PDE 1–6的抑制效果比较 Sáenz de Tejada I, e