皮肤性病学课件：药疹（英文版）.pptVIP

Drug eruption taking oral sulfamethoxazole-rimethoprim(SMZ-TMP)for a urinary tract infection(泌尿道感染)FIXED DRUG REACTION （固定型药疹）leaving persistent hyperpigmentation(遗留持久的色素沉着斑)斑疹maculaContact dermatitis？erysipelas ？Developing?Case 1 Caused by the rabies antivenom and rabies vaccine. His lesions characterized by urticaria, and accompanied by joint pain, abdominal pain and other symptoms. Urticarial drug eruptions（荨麻疹样型药疹）风团whealCase 2 　　Caused by penicillin. Onset suddenly, accompanied by chills, fever, such as disease, skin lesions of measles rash, there is no internal organs damage. Morbilliform drug eruptions（麻疹样型药疹）斑疹Macula丘疹papule measles ？eczema？case3 bullous epidermal necrolysis, BEN（大疱性表皮松解型药疹）水疱 blister糜烂erosionLarge area burn ？pemphigus ？SSSS？caused by antipyretics ！！case4 Difinition Drug eruption (dermatitis medicamentosa) medicines can lead to drug eruption by many ways : oral taking ,injection, inhalation, clusis , suppository, or even tiny wound of skin ;drug eruption always shows inflammatory lesions ; it can also effect on other systems in some severe cases. Most drug eruptions are mild, self-limitedDrug Eruption prognosisSevere and potentially life-threatening eruptions occur in approximately 1 in 1000 hospital patientsDHS has a mortality rate 10%, TEN approaches 20-30%; etiology and pathogenesis Etiology Individual difference medicine medicineAntibiotics Antipyretic and analgesic Sedatives and hypnotics Antiepileptic and antispasmodic Serum of other species and vaccine Traditional Chinese medicine allergic reaction non-allergic reactionHow do drugs lead to drug eruption? Features of allergic drug eruption 1. It occurs only some individuals who have allergic constitutions. 2. Therapeutic action,toxic reaction and dose of drugs do not determine degrees of the eruption. 3. Drug eruption has a special latent peri