肝细胞癌分子靶向治疗研究进展.pptVIP

Bisphosphonates Overview * Bisphosphonates Overview * Bisphosphonates Overview * * * HCC的分子发病机制极其复杂，信号传导途径异常导致细胞异常增生和无限制增殖。 异常的生长因子激活 (TGF-β, EGFR)； 细胞分裂信号途径持续活化 (Raf/MEK/ERK, PI3K/AKT/mTOR , Wnt／?-catenin) ； 抗细胞凋亡信号途径失调 (p53, PTEN)。 新生血管异常增生（如VEGF途径）促进HCC生长及进展。 Bisphosphonates Overview * Role of angiogenesis in cancer development, growth and metastasis. A switch to an angiogenic phenotype is a prerequisite for the development from a premalignant stage to an invasive tumor. The neovascularization provides not only nutrients for tumor growth but also a large surface area of leaky vessels w